Invention Grant
- Patent Title: T cell receptors recognizing HLA-A1- or HLA-CW7-restricted mage
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Application No.: US16144226Application Date: 2018-09-27
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Publication No.: US11306131B2Publication Date: 2022-04-19
- Inventor: Paul F. Robbins , Steven A. Rosenberg , Shiqui Zhu , Steven A. Feldman , Richard A. Morgan
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer
- Main IPC: C07K14/725
- IPC: C07K14/725 ; C07K14/705 ; G01N33/574 ; C07K16/28 ; A61K39/00
Abstract:
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a) melanoma antigen family A (MAGE A)-3 in the context of HLA-A1 or b) MAGE-A12 in the context of HLA-Cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
Public/Granted literature
- US20190016777A1 T CELL RECEPTORS RECOGNIZING HLA-A1- OR HLA-CW7-RESTRICTED MAGE Public/Granted day:2019-01-17
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