Invention Grant
- Patent Title: Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions
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Application No.: US16327605Application Date: 2017-09-22
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Publication No.: US11306305B2Publication Date: 2022-04-19
- Inventor: Keith Gagnon , Masad Damha , Elise Malek-Adamian , Maryam Habibian , Daniel Timothy O'Reilly , Zachery Kartje
- Applicant: Board of Trustees of Southern Illinois University , The Royal Institution for the Advancement of Learning/McGill University
- Applicant Address: US IL Springfield; CA Montreal
- Assignee: Board of Trustees of Southern Illinois University,The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee: Board of Trustees of Southern Illinois University,The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee Address: US IL Springfield; CA Montreal
- Agency: Husch Blackwell LLP
- International Application: PCT/US2017/053041 WO 20170922
- International Announcement: WO2018/057946 WO 20180329
- Main IPC: C12N15/10
- IPC: C12N15/10 ; A61K48/00 ; C12N9/22 ; C12N15/11 ; C12N15/113 ; C12N15/90
Abstract:
The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
Public/Granted literature
- US20190185844A1 Tuning CRISPR/CAS9 Activity with Chemically Modified Nucleotide Substitutions Public/Granted day:2019-06-20
Information query
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