A low power operation method provides an apparatus with a data transmission rate. A power management unit (PMU), which is not influenced by voltage, process, and temperature, biases a high frequency oscillator (HOSC) and makes the HOSC generate a steady and high precision clock. The clock of the HOSC is used to modify a timing length of a timer which is referenced by a low frequency oscillator (LOSC) without PMU. At last, through the modified timing length, the apparatus achieves high precision periods and data transmissions with compensation for voltage, process, and temperature. Thus, the data transmission cycles of the apparatus maintain stable and robust even if the apparatus applies duty cycle usage of the HOSC and the PMU for reducing power consumption with actions of turning on and turning off. Consequently, the periodic apparatus maintains data transmission rate with the low power consumption advantage of non-periodic apparatus.