Described herein are systems and methods for dynamic designation of instructions as sensitive. For example, some methods include detecting that a first instruction of a first process has been designated as a sensitive instruction; checking whether a sensitive handling enable indicator in a process state register storing a state of the first process is enabled; responsive to detection of the sensitive instruction and enablement of the sensitive handling enable indicator, invoking a constraint for execution of the first instruction; executing the first instruction subject to the constraint; and executing a second instruction of the first process without the constraint.