A system and method are provided for optimizing histogram cumulative distribution function curves. In use, a first cumulative distribution function for a first histogram of a first pixel region of a first image is computed, and a first set of parameters for the first cumulative distribution function is extracted. A second cumulative distribution function for a second histogram of a second pixel region of the first image is computed, and a second set of parameters for the second cumulative distribution function is extracted. An interpolated cumulative distribution function comprising interpolated parameters calculated by interpolating between the first set of parameters and the second set of parameters is created. Additionally, a first equalized pixel in a second image based on a first input pixel in the first image and the interpolated cumulative distribution function is generated.