Provided are a driving method and driving device of a display panel, and a display device. A sub-display region in which gray scale values of first sub-pixels are 0 and gray scale values of second sub-pixels are less than a first preset gray scale value is determined as a first sub-display region, and a sub-display region in which not all of the gray scale values of the first sub-pixels are 0 and not all of the gray scale values of the second sub-pixels are less than the first preset gray scale value is determined as a second sub-display region. In a reset stage, a first reset signal is provided to an anode of an organic light emitting element of a sub-pixel of the first sub-display region and a second reset signal is provided to an anode of an organic light emitting element of a sub-pixel of the second sub-display region.