A stringed instrument pickup and feedback system, comprising a sound pickup device disposed on a string instrument. The sound pickup device comprises a transducer and at least one pickup, a sound processing circuit and a power supply. The pickup activates the transducer to realize resonance enhancement on the instrument body. The transducer is disposed on the string instrument unrestricted by internal bracing. The instrument can be any of pickup, guitar, ukulele, violin, Guqin, Guzheng and Mandolin. The present invention enables the construction of stringed instrument to add vibration and amplify sound of a stringed instrument using the transducer and thus reduce the dependence on rare woods in manufacturing these instruments.