A multi-functional optical composite board having quantum dots of high uniformity is provided herein, the multi-functional optical composite board comprises a diffusion base layer, a first quantum dot-containing layer disposed on the lower surface of the diffusion base layer, and a second quantum dot-containing layer disposed on the upper surface of the diffusion base layer, wherein the first quantum dot-containing layer comprises a red quantum dot-containing layer and a green quantum dot-containing layer, and the second quantum dot-containing layer is sequentially deposited on the upper surface of the diffusion base layer by coating repeatedly. The present invention improves the optical composite board from the structure, raw material and compositions thereof, and obtains a multi-functional optical composite board having a high light diffusion, a high uniformity of emitting-light, and the emitting-light of the resultant product appears much whiter and brighter.