Disclosed are systems, methods, and non-transitory computer-readable media for variable termination in a vehicle communication bus. To provide compatibility with multiple vehicles, a device may include a software selectable terminator resistor that can be programmatically enabled or disabled to add or remove resistance as needed. For example, the software selectable terminator resistor may be enabled when the device is added as an end node in a high-speed communication bus and operates as a terminator resistor. Alternatively, the software selectable terminator resistor may be disabled when the device is added as an intermediate node positioned between terminator resistors in the high-speed communication bus.