According to certain embodiments, a method is performed by a wireless device configured with multiple power control closed loops for a serving cell. The method comprises receiving a transmit power control (TPC) command in a downlink control message that comprises a plurality of TPC commands. The method comprises determining a particular power control closed loop of the plurality of power control closed loops to which the TPC command should be applied. The particular power control closed loop is determined using the downlink control message. The method further comprises updating the particular power control closed loop using the TPC command.