Systems and methods relating to selection of user plane functions in a core network and a radio access network of a cellular communications network that take into consideration information related to application server selection are disclosed. In some embodiments, a method of operation of a network node in a cellular communications network that comprises a radio access network and a core network comprises selecting a user plane function for a protocol data unit session for a wireless device based on information related to application server selection such that the protocol data unit session for the wireless device utilizes the selected user plane function. In this manner, optimal user plane connectivity between an application client in the wireless device and an application server is provided.