Embodiments of the present disclosure provide a device for determining a location of a blood vessel and a method thereof. The device includes a plurality of sensors, a processor, and an indicating device. The plurality of sensors may detect pressure values at a plurality of skin locations in contact with the plurality of sensors. The processor may determine the location of the blood vessel based on the pressure values. The pressure value at the skin location corresponding to the location of the blood vessel is greater than the pressure values at both sides of the skin location in a direction perpendicular to a direction of the blood vessel. The indicating device may indicate the location of the blood vessel.