A method and apparatus for Secure Storage and Dispensing of Opioid (SSDO) or other controlled substances while providing remote assistance and monitoring. In one embodiment, the apparatus comprises a motorized medication tray for automatic dispensing of pills with optional blister pack containing sealed medication. The device further comprises of a secure tamper resistant housing mechanism, plurality of sensors along with a wireless communication module to notify the remote operators in case of illegal and unauthorized access. The current invention can be configured into multiple embodiments including but not limited to a mobile wearable device capable of attaching to a person's wrist, arm, foot and other body parts.