- Patent Title: Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
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Application No.: US16980594Application Date: 2019-03-15
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Publication No.: US11311528B2Publication Date: 2022-04-26
- Inventor: Michael D. Altman , Matthew L. Childers , James P. Jewell , Charles A. Lesburg , Tony Siu
- Applicant: Merck Sharp & Dohme Corp. , Michael D. Altman , Matthew L. Childers , James P. Jewell , Charles A. Lesburg , Tony Siu
- Applicant Address: US NJ Rahway; US MA Needham; US MA Medfield; US MA Newton; US MA Waban; US MA Brookline
- Assignee: Merck Sharp & Dohme Corp.,Michael D. Altman,Matthew L. Childers,James P. Jewell,Charles A. Lesburg,Tony Siu
- Current Assignee: Merck Sharp & Dohme Corp.,Michael D. Altman,Matthew L. Childers,James P. Jewell,Charles A. Lesburg,Tony Siu
- Current Assignee Address: US NJ Rahway; US MA Needham; US MA Medfield; US MA Newton; US MA Waban; US MA Brookline
- Agent Patricia A. Shatynski; John C. Todaro
- International Application: PCT/US2019/022440 WO 20190315
- International Announcement: WO2019/182886 WO 20190926
- Main IPC: C07D405/10
- IPC: C07D405/10 ; C07D405/14 ; C07D409/04 ; C07D411/04 ; C07D413/04 ; C07D413/14 ; C07D417/14 ; A61K31/4725 ; A61K31/497 ; A61K31/5377 ; A61K31/538
Abstract:
The instant invention provides compounds of formula I which are STING inhibitors, and as such are useful for the treatment of STING-mediated diseases such as inflammation, asthma, COPD and cancer.
Public/Granted literature
- US20210052573A1 OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS Public/Granted day:2021-02-25
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