Invention Grant
- Patent Title: Treatment of GVHD
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Application No.: US15303420Application Date: 2015-04-09
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Publication No.: US11311541B2Publication Date: 2022-04-26
- Inventor: Alexandra Zanin-Zhorov , Bruce Robert Blazar , Ryan Flynn
- Applicant: KADMON CORPORATION, LLC , REGENTS OF THE UNIVERSITY OF MINNESOTA
- Applicant Address: US NY New York; US MN Minneapolis
- Assignee: KADMON CORPORATION, LLC,REGENTS OF THE UNIVERSITY OF MINNESOTA
- Current Assignee: KADMON CORPORATION, LLC,REGENTS OF THE UNIVERSITY OF MINNESOTA
- Current Assignee Address: US NY New York; US MN Minneapolis
- Agency: Fox Rothschild LLP
- International Application: PCT/US2015/025176 WO 20150409
- International Announcement: WO2015/157556 WO 20151015
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/506 ; C07D401/12 ; C07D239/42 ; C07D491/052 ; C07D413/14 ; C07D403/14 ; C07D498/04 ; C07D495/04 ; C07D239/30 ; C07D403/12 ; C07D401/14 ; C07D417/14 ; C07D491/048 ; C07D471/04 ; C07D519/00 ; C07D513/04 ; C07D487/04 ; C07D409/14 ; C07D239/48 ; C07D239/47 ; A61K31/519 ; A61K31/517 ; A61K31/53 ; A61K31/5377 ; A61K31/541 ; A61K31/551
Abstract:
The invention relates to treatment of graft versus host disease (GVHD) using compounds that inhibit ROCK2. In preferred aspects, the present invention provides methods for the treatment of GVHD, including chronic GVHD (cGVHD) using compounds having the formulae 1-XXV, as set forth herein.
Public/Granted literature
- US20170112832A1 TREATMENT OF GVHD Public/Granted day:2017-04-27
Information query
