Invention Grant
- Patent Title: Enhancing chemotherapy in medulloblastoma and glioblastoma with high basal p53 levels
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Application No.: US16979817Application Date: 2019-03-12
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Publication No.: US11311606B2Publication Date: 2022-04-26
- Inventor: Christopher Albanese , Aisha Naeem
- Applicant: GEORGETOWN UNIVERSITY
- Applicant Address: US DC Washington
- Assignee: GEORGETOWN UNIVERSITY
- Current Assignee: GEORGETOWN UNIVERSITY
- Current Assignee Address: US DC Washington
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2019/021797 WO 20190312
- International Announcement: WO2019/178059 WO 20190919
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/22 ; A61P35/00 ; A61K31/475 ; A61K31/704
Abstract:
Provided herein is a method of treating medulloblastoma or glioblastoma in a subject by administering to the subject a PI3K activator (e.g., thymosin β-4 or a derivative thereof) and one or more chemotherapeutic agents and/or radiation. The combination therapy is effective in the treatment of medulloblastoma or glioblastoma characterized by cells with elevated p53 levels.
Public/Granted literature
- US20210244797A1 ENHANCING CHEMOTHERAPY IN MEDULLOBLASTOMA AND GLIOBLASTOMA WITH HIGH BASAL p53 LEVELS Public/Granted day:2021-08-12
Information query
IPC分类:
