- Patent Title: Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds
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Application No.: US16637305Application Date: 2018-08-08
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Publication No.: US11311624B2Publication Date: 2022-04-26
- Inventor: Brian D. Ross , Marcian Van Dort
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2018/045703 WO 20180808
- International Announcement: WO2019/032640 WO 20190214
- Main IPC: A61K47/60
- IPC: A61K47/60 ; A61K47/54 ; C07C259/10 ; C07D239/48 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D471/04
Abstract:
Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.
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