Invention Grant
- Patent Title: DNA-templated micelle and uses thereof
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Application No.: US16492320Application Date: 2018-02-27
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Publication No.: US11311629B2Publication Date: 2022-04-26
- Inventor: Kam W. Leong , Yeh-Hsing Lao , Tzu-Chieh Ho , Smruthi Suryaprakash
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg; Scott H. Blackman
- International Application: PCT/US2018/019926 WO 20180227
- International Announcement: WO2018/164883 WO 20180913
- Main IPC: A61K47/69
- IPC: A61K47/69 ; A61K47/55 ; A61K47/64 ; A61K47/68 ; A61K47/54 ; A61K47/60 ; A61P35/02 ; A61K31/136 ; A61K31/4178 ; A61K31/7105 ; A61K38/46 ; A61K48/00 ; C12N15/88
Abstract:
The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
Public/Granted literature
- US20210128746A1 DNA-TEMPLATED MICELLE AND USES THEREOF Public/Granted day:2021-05-06
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