Systems and methods for directing a device to a target region within a body cavity are provided. One embodiment includes a first catheter having a handle, an expandable cage, and a lumen therethrough, the expandable cage having a plurality of members that expand to engage a wall of the body cavity, a second catheter within the first catheter lumen having a hub at a distal end, and a plurality of pairs of wires secured at a first end within the handle of the first catheter and secured at a second end to the hub of the second catheter, each pair of wires being movable in conjunction with each other by manipulation of the handle so as to move the hub, a first pair of wires movable to move the hub in a first direction and a second pair of wires movable to move the hub in a second direction.