Packages made from flexible material, wherein the packages include one or more self-folds formed by applying activation energy to the flexible material are presented. The packages include a polymeric film, wherein the polymeric film is formed from one type of polymer, and wherein the flexible material defines an enclosed product volume. The packages include a first panel formed from the flexible material and a second panel formed from the flexible material. The packages include a self-fold that has an overall thickness that is about 5% to about 30% greater than a thickness of the flexible material outside of the self-fold. The self-fold has a differential thermal-mechanical set than the flexible material outside of the self-fold, and forms an angle of about 100 degrees to about 170 degrees between the first panel and the second panel.