Invention Grant
- Patent Title: ABHD5 and partial HDAC4 fragments and variants as a therapeutic approach for the treatment of cardiovascular diseases
-
Application No.: US15881935Application Date: 2018-01-29
-
Publication No.: US11312943B2Publication Date: 2022-04-26
- Inventor: Johannes Backs , Zegeye Jebessa , Lorenz Lehmann , Hugo Katus , Oliver Müller
- Applicant: Ruprecht-Karls-Universität Heidelberg
- Applicant Address: DE Heidelberg
- Assignee: Ruprecht-Karls-Universität Heidelberg
- Current Assignee: Ruprecht-Karls-Universität Heidelberg
- Current Assignee Address: DE Heidelberg
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/12 ; A61K38/48 ; C12N9/80 ; C12N9/10 ; A61K38/45 ; A61K38/50 ; C12Q1/48
Abstract:
The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.
Public/Granted literature
Information query
IPC分类:
