Invention Grant
- Patent Title: Enhanced acyltransferase polynucleotides, polypeptides and methods of use
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Application No.: US14438758Application Date: 2013-10-22
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Publication No.: US11312971B2Publication Date: 2022-04-26
- Inventor: Nicholas John Roberts , Amy Christina Curran , Somrutai Winichayakul , Marissa Roldan , Richard William Scott
- Applicant: Agresearch Limited
- Applicant Address: NZ Hamilton
- Assignee: Agresearch Limited
- Current Assignee: Agresearch Limited
- Current Assignee Address: NZ Hamilton
- Agency: Leydig, Volt & Mayer, Ltd.
- International Application: PCT/IB2013/059524 WO 20131022
- International Announcement: WO2014/068437 WO 20140508
- Main IPC: C12N15/82
- IPC: C12N15/82 ; C12N9/10 ; C12P7/64
Abstract:
The invention provides modified DGAT1 proteins that are modified in the N-terminal region upstream of the acyl-Co A binding site. The modified DGAT proteins show enhanced activity, without reduced protein accumulation when expressed in cells. The modified DGAT1 proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the modified DGAT1 proteins, cells and compositions comprising the polynucleotides or modified DGAT proteins, and methods using the modified DGAT1 proteins to produce oil.
Public/Granted literature
- US20150275223A1 Enhanced Acyltransferase Polynucleotides, Polypeptides and Methods of Use Public/Granted day:2015-10-01
Information query
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