An integrated chemical sensor device includes a chemical sensor comprising at least one transistor and having an external sensing surface electrically coupled to a node of the at least one transistor. There is an initialization circuit connected to the base of the at least one transistor configured to set an operating point for the at least one transistor. There is a temperature sensor control circuit coupled to the chemical sensor circuit. The temperature sensor includes a temperature sensor, an analog-to-digital (A/D) converter coupled to the temperature sensor, and a proportional-to-absolute-temperature (PTAT) circuit configured to generate a PTAT reference voltage for temperature compensation. The temperature sensor control circuit is configured to compensate for a change in temperature of the at least one transistor.