A method and system for white box infection detection and isolation. The methods and systems can monitor a plurality of white boxes deployed within a communications network; send a challenge to a first white box of the plurality of white boxes; determine a processing time to answer the challenge by the first white box; in response to receiving the answer to the challenge, determine whether the processing time exceeds an average processing time for the challenge by a predetermined percentage; and in response to the processing time exceeding the average processing time by the predetermined percentage, isolate the first white box from the communications network.