- Patent Title: Genetically modified non-human animal with human or chimeric PD-L1
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Application No.: US16329376Application Date: 2017-08-30
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Publication No.: US11317611B2Publication Date: 2022-05-03
- Inventor: Yuelei Shen , Yang Bai , Yanan Guo , Rui Huang , Xiaofei Zhou , Chaoshe Guo
- Applicant: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
- Applicant Address: CN Beijing
- Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
- Current Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
- Current Assignee Address: CN Beijing
- Agency: Fish & Richardson P.C.
- Priority: CN201610775382.4 20160831,CN201710757022.6 20170829
- International Application: PCT/CN2017/099574 WO 20170830
- International Announcement: WO2018/041118 WO 20180308
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C07H21/04 ; C12N15/63 ; C07K14/705 ; C12N15/90 ; C12N15/85
Abstract:
Non-human animals, methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanized programmed death-ligand 1 (PD-L1, PDL1, or B7-H1). Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous PD-L1 gene so that the non-human animals express a humanized PD-L1 protein that includes a human portion and an endogenous portion (e.g., a non-human portion).
Public/Granted literature
- US20190281798A1 Genetically Modified Non-Human Animal With Human Or Chimeric PD-L1 Public/Granted day:2019-09-19
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