The present invention discloses an integrally-formed flexible rubber applicator stick, and relates to the technical field of applicator sticks. The integrally-formed flexible rubber applicator stick includes a stick body that is connected to a soft connection region at one end thereof and connected to a handle at the other end thereof; a bristle head is mounted at an end of the soft connection region, and has multiple soft rubber bristles distributed thereon; an annular discarding groove is set up between the handle and the stick body; and an anti-slip thread is set up on the end of the stick body that is adjacent to the soft connection region. The integrally-formed flexible applicator stick provided by the present invention makes the production process simple and is not prone to losing bristles during use.