An exemplary system includes an electro-acoustic stimulation (“EAS”) sound processor, a cochlear implant communicatively coupled to the EAS sound processor, an electrode array communicatively coupled to the cochlear implant, and a receiver communicatively coupled to the EAS sound processor and configured to be in communication with an ear of a patient. The EAS sound processor 1) directs, while in a self-fitting mode, the receiver to apply acoustic stimulation to the patient, 2) records, using at least one electrode included in the electrode array, an evoked response that occurs in response to the acoustic stimulation, 3) compares the evoked response to a baseline evoked response recorded by the EAS sound processor prior to recording the evoked response, and 4) performs a predetermined action based on the comparison between the evoked response and the baseline evoked response. Corresponding systems and methods are also disclosed.