Invention Grant
- Patent Title: Hsp90 activator Aha1 drives production of pathological tau aggregates
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Application No.: US16486975Application Date: 2018-02-23
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Publication No.: US11318155B2Publication Date: 2022-05-03
- Inventor: Chad Dickey , Lindsey Shelton , Brian Blagg , John Koren , Laura Blair
- Applicant: University of South Florida , University of Kansas
- Applicant Address: US FL Tampa; US KS Lawrence
- Assignee: University of South Florida,University of Kansas
- Current Assignee: University of South Florida,University of Kansas
- Current Assignee Address: US FL Tampa; US KS Lawrence
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2018/019568 WO 20180223
- International Announcement: WO2018/156989 WO 20180830
- Main IPC: A61K31/7048
- IPC: A61K31/7048 ; A61P25/28 ; A61K31/366
Abstract:
Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.
Public/Granted literature
- US20210128597A1 THE HSP90 ACTIVATOR AHA1 DRIVES PRODUCTION OF PATHOLOGICAL TAU AGGREGATES Public/Granted day:2021-05-06
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