Invention Grant
- Patent Title: 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors
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Application No.: US16825024Application Date: 2020-03-20
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Publication No.: US11318157B2Publication Date: 2022-05-03
- Inventor: Tongfei Wu , Dirk Brehmer , Lijs Beke , An Boeckx , Gaston Stanislas Marcella Diels , Ronaldus Arnodus Hendrika Joseph Gilissen , Edward Charles Lawson , Vineet Pande , Marcus Cornelis Bernardus Catharina Paradé , Wim Bert Griet Schepens , Johannes Wilhelmus John F. Thuring , Marcel Viellevoye , Weimei Sun , Lieven Meerpoel
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agency: BakerHostetler
- Priority: EP15184011 20150907
- Main IPC: A61K31/7076
- IPC: A61K31/7076 ; A61K31/519 ; A61K31/53 ; C07D471/04 ; A61P35/00 ; A61K31/5025
Abstract:
Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound: Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).
Information query
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