An example system for suppressing a fire condition in an aircraft includes a supply of fire suppressant agent on-board the aircraft, a conduit coupled to the supply of fire suppressant agent and configured to carry fire suppression agent, an inlet located downstream of the conduit that is coupled to the conduit and is configured to be attached to a cargo container in the aircraft to deliver the fire suppression agent directly into the cargo container, a valve connected to the conduit between the supply of fire suppressant agent and the inlet, a detector located inside the cargo container, and a computer controller in communication with the valve and in communication with the detector, and controlling operation of the valve for delivery of the fire suppression agent into the cargo container based on an output received from the detector.