- Patent Title: Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors
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Application No.: US16759262Application Date: 2018-10-18
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Publication No.: US11319324B2Publication Date: 2022-05-03
- Inventor: Marcus Koppitz , Holger Siebeneicher , Nico Bräuer , Elisabeth Pook , Andrea Rotgeri , Roland Neuhaus , Oliver Martin Fischer , Jens Nagel , Adam James Davenport , James Lindsay Carr , Robert James Townsend , Nina Connelly Ursinyova , Shelley Anne Parrott
- Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
- Applicant Address: DE Leverkusen; DE Berlin
- Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- Current Assignee: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- Current Assignee Address: DE Leverkusen; DE Berlin
- Agency: Morrison & Foerster LLP
- Priority: EP17198769 20171027
- International Application: PCT/EP2018/078567 WO 20181018
- International Announcement: WO2019/081343 WO 20190502
- Main IPC: C07D487/14
- IPC: C07D487/14
Abstract:
The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20210317128A1 NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS Public/Granted day:2021-10-14
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