Invention Grant
- Patent Title: Method and apparatus for screening compounds that have preventative and therapeutic activities against endothelial glycocalyx-related diseases
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Application No.: US16712724Application Date: 2019-12-12
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Publication No.: US11319519B2Publication Date: 2022-05-03
- Inventor: Yong Luo , Jinhua Wei , Zhou Wang , Ming Sun , Chen Chen , Yuguang Du
- Applicant: MACAU GLCAO Biotechnology Research Center Limited , Calroy Health Sciences, LLC
- Applicant Address: CN Macau; US AZ Scottsdale
- Assignee: MACAU GLCAO Biotechnology Research Center Limited,Calroy Health Sciences, LLC
- Current Assignee: MACAU GLCAO Biotechnology Research Center Limited,Calroy Health Sciences, LLC
- Current Assignee Address: CN Macau; US AZ Scottsdale
- Agency: Thorpe, North & Western
- Main IPC: C12M3/06
- IPC: C12M3/06 ; C12M1/12 ; C12N5/077 ; B01L3/00 ; C12M1/00 ; C12N5/071 ; C12M1/36

Abstract:
The microfluidic chip can comprise at least one multichamber flow assembly that can comprise a plurality of microchannels. The plurality of microchannels can comprise a first microchannel that includes: a first inlet; a first outlet; and a first chamber fluidly connected to the first inlet and the first outlet. The plurality of microchannels can comprise a second microchannel that includes: a second inlet; a second outlet; and a second chamber fluidly connected to the second inlet and the second outlet. The multichamber flow assembly can comprise a porous biocompatible membrane oriented along a longitudinal interface between the first microchannel and the second microchannel, wherein the porous biocompatible membrane is permeable for movement of biomolecules from the first chamber to the second chamber through the porous biocompatible membrane.
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