A portable temperature regulation device includes a wearing body and first and second main bodies rotatably connected to the wearing body. The first and second main bodies each include a first housing in which a first receiving chamber is formed to receive a first fan therein. The first main body further includes a first air passage in communication with the first receiving chamber, a first air outlet communicating the first air passage and outside, an air inlet in communication with the first receiving chamber. The first and second main bodies are rotatably connected to the wearing body by a rotation structure. When it needs to fold for storage, the first and second main bodies can be rotated to a folded state, so as to reduce the size of the portable temperature regulation device for easy storage by a user.