A caliper for an opposed-piston disc brake, includes a pair of bodies provided at two sides of a rotor that rotates with a wheel, each of the bodies including five cylinders. A central cylinder among the five cylinders provided on each of the bodies, which is surrounded by four of the cylinders, has a center which is located in a region on a radially inner side relative to an outer reference circle and on a radially outer side relative to an inner reference line. The outer reference circle passes through a center of a cylinder provided on a radially outermost side among the four of the cylinders and has a center thereof on a center of the rotor. The inner reference line passes through centers of two of the cylinders provided on a radially inner side among the four of the cylinders.