A fluid manifold segment operable for detachably coupling with another instance of the fluid manifold segment to form a fluid manifold assembly. The fluid manifold segment may include a plurality of pressure exchangers each having a clean fluid inlet a clean fluid outlet, a dirty fluid inlet, and a dirty fluid outlet. The fluid manifold segment may further include a first fluid conduit having opposing end ports and intermediate ports, a second fluid conduit having opposing end ports and intermediate ports each fluidly connected with the clean fluid outlet of a corresponding pressure exchanger, a third fluid conduit having opposing end ports and intermediate ports each fluidly connected with the dirty fluid inlet of a corresponding pressure exchanger, and a fourth fluid conduit having opposing end ports and intermediate ports each fluidly connected with the dirty fluid outlet of a corresponding pressure exchanger.