The disclosure provides high voltage interlock circuit and detection method. The circuit comprises: a power module, a positive electrode of the power module being connected to one end of a current generating module; the current generating module, the other end of the current generating module being connected to a first terminal of a high voltage component module to inject a constant DC current into the high voltage component module; a first voltage dividing module, one end of the first voltage dividing module being connected to a second terminal of the high voltage component module, and the other end of the first voltage dividing module being connected to a negative electrode of the power module and a power ground; and a processing module to determine a fault of the high voltage component module based on a first voltage collected from the second terminal of the high voltage component module.