Example implementations relate to safe peripheral device communications. In one example, a host computing device can include a serializer/deserializer (SERDES), a PCIe bus, a video source, a connector coupled, via the SERDES, to the PCIe bus and the video source; and a host controller to operate in a safe mode and cause PCIe data from PCIe bus to be provided, via the SERDES and the connector, solely to a peripheral controller of a peripheral device.