Systems, computer-implemented methods, and computer program products to facilitate state dependent calibration of qubit measurements are provided. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a state prediction component that predicts a readout state of one or more qubits of a quantum circuit. The computer executable components can further comprise a calibration component that calibrates a qubit readout signal based on the readout state to generate a state dependent qubit readout signal to read the one or more qubits.