In various examples, a signal processing pipeline is dynamically generated or instantiated for a signal processing request. To generate the pipeline, a graph topology—including nodes and edges—may be created to represent features, functionality, and characteristics of a signal processing system. The nodes, representing processing tasks, may be connected via edges having associated costs for performing, by a node, a processing task on an output of a prior or edge-connected node. For a given signal processing request, the nodes or processing tasks to be included may be selected and, using a graph routing algorithm and the costs between and among the determined nodes, a path through the nodes may be determined—thereby defining, at least in part, the signal processing pipeline.