This application provides an over-drive compensation method and a device thereof. The over-drive compensation method includes: receiving three primary color information of a current frame, and converting the three primary color information into color space information with luminance, to obtain a current luminance information from the color space information; buffering and storing the current luminance information in a buffer memory and outputting, by the buffer memory, previous luminance information of a previous frame; and generating a luminance over-drive gain value according to the current luminance information and previous luminance information; converting the luminance over-drive gain value into a three primary color over-drive gain value; and generating, according to the three primary color information and the three primary color over-drive gain values, corresponding over-drive compensated values for output to over-drive the liquid crystal display panel.