A system for self-fulfillment of an alimentary instruction set based on vibrant constitutional guidance using artificial intelligence. The system includes a computing device designed and configured to receive training data. The computing device is further configured to record at least a biological extraction from a user and generate a diagnostic output. The computing device is further configured to generate a self-fulfillment instruction set utilizing the diagnostic output. The computing device is further configured to receive a user entry containing a completed alimentary self-fulfillment action. The computing device is further configured to update the self-fulfillment instruction set as a function of an alimentary self-fulfillment action.