An operation method of a first AN for a hybrid beamforming-based cooperative transmission in a C-RAN includes obtaining a spatial channel covariance with terminals subject to a service; selecting a set of terminals to be serviced from among the terminals subject to the service; determining a radio frequency (RF) precoding matrix by which interference between the terminals to be serviced is minimized; transferring information on the determined RF precoding matrix to a centralized processor (CP); and generating an effective channel by configuring an RF precoder based on the determined RF precoding matrix.