Techniques for optimal interference handling in a multicell environment when conditional cell changeover is configured are disclosed. A user equipment (UE) may receive a conditional changeover command (e.g., conditional handover (CHO), conditional primary secondary cell (PSCell) change CPC)) from a serving cell. The conditional changeover command may include a neighbor cell configuration of a neighbor cell set comprising one or more cells that neighbor the serving cell. The neighbor cell configuration may indicate resource configurations of downlink (DL) resources the neighbor cell set. The UE may utilize the neighbor cell configuration to determine potential interferences due to the resources of the serving cell colliding with the resources of the neighbor cell set, and take mitigation steps to address the potential interferences.