A luminal endoprosthesis (1) at least partially delimits a prosthesis lumen (2), for implantation in an anatomical structure (3) that at least partially defines at least one cavity (4) and includes a pathological portion (13). The luminal endoprosthesis (1) includes two or more layers (5, 6, 7), at least one layer (5, 6, 7) having at least one threadlike element (8) forming an armor (9). The luminal endoprosthesis (1) includes an anchoring portion (10), for anchoring to an anatomical portion (11) of the walls of the cavity (4) of the anatomical structure (3). A working portion (12) faces the pathological portion (13) of the anatomical structure (3). The two or more layers (5, 6, 7) are separated from each other at least in the working portion (12) of the luminal endoprosthesis (1), avoiding connecting elements between one layer (5, 6, 7) and at least one adjacent layer.