Invention Grant
- Patent Title: Sustained drug release sheet for treating nerve injury
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Application No.: US16082594Application Date: 2017-03-06
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Publication No.: US11324704B2Publication Date: 2022-05-10
- Inventor: Hiroyuki Tanaka , Kiyoshi Okada , Hideki Yoshikawa , Koji Suzuki , Mitsuhiro Ebara
- Applicant: OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Suita; JP Tsukuba; JP Osaka
- Assignee: OSAKA UNIVERSITY,NATIONAL INSTITUTE FOR MATERIALS SCIENCE,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- Current Assignee: OSAKA UNIVERSITY,NATIONAL INSTITUTE FOR MATERIALS SCIENCE,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Suita; JP Tsukuba; JP Osaka
- Agency: Oliff PLC
- Priority: JP2016-043873 20160307,JP2017-008913 20170120,JP2017-037270 20170228
- International Application: PCT/JP2017/008730 WO 20170306
- International Announcement: WO2017/154822 WO 20170914
- Main IPC: A61K9/70
- IPC: A61K9/70 ; A61K47/34 ; A61K47/36 ; A61K31/714 ; A61K35/36 ; A61K45/00 ; A61K38/18 ; A61P25/02 ; A61K47/32

Abstract:
Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
Public/Granted literature
- US20190083415A1 SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE INJURY Public/Granted day:2019-03-21
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