This disclosure relates to procedures for administering a blockade of the sphenopalatine ganglion (“SPG”). Methods may include advancing a catheter through nostril at least 8 cm. Methods may include advancing the catheter through an inferior meatus. Methods may include causing the catheter to bend after contacting posterior wall of the nasal cavity. Methods may include advancing the catheter superiorly to a position posterior to the middle turbinate. Methods may include advancing the catheter superiorly to a position posterior to the superior turbinate. Methods may include advancing the catheter superiorly into a sphenoethmoid recess. Methods may include bringing a distal tip of the catheter in contact with the SPG. Methods may include ejecting an anesthetic from a distal tip of the catheter and bathing the SPG to administer a blockade of the SPG.