Invention Grant
- Patent Title: Ketone inhibitors of lysine gingipain
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Application No.: US16899376Application Date: 2020-06-11
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Publication No.: US11325884B2Publication Date: 2022-05-10
- Inventor: Andrei W. Konradi , Robert A. Galemmo, Jr. , Stephen S. Dominy , Casey C. Lynch , Leslie J. Holsinger
- Applicant: CORTEXYME, INC.
- Applicant Address: US CA South San Francisco
- Assignee: CORTEXYME, INC.
- Current Assignee: CORTEXYME, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07C233/62
- IPC: C07C233/62 ; C07D213/82 ; C07D239/34 ; C07D239/36 ; C07D413/12 ; C07D257/04 ; C07D261/12 ; C07D213/70 ; C07C317/28 ; C07C233/78 ; C07C235/10 ; C07C235/50 ; C07B59/00 ; C07C237/42 ; C07D401/12 ; C07C381/00 ; C07C323/42 ; C07D213/65 ; C07D213/68 ; C07D239/38 ; C07C247/18 ; C07F5/02 ; A61P31/04 ; A61P25/00 ; A61K31/165 ; A61K31/167 ; A61K31/41 ; A61K31/42 ; A61K31/44 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/4439 ; A61K31/505 ; A61K31/513 ; A61K31/655 ; A61K45/06 ; C07C245/08 ; C07C247/16 ; C07C323/40 ; C07D213/81
Abstract:
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
Public/Granted literature
- US20210053908A1 KETONE INHIBITORS OF LYSINE GINGIPAIN Public/Granted day:2021-02-25
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