• Patent Title: Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid
  • Application No.: US16765350
    Application Date: 2018-11-14
  • Publication No.: US11325909B2
    Publication Date: 2022-05-10
  • Inventor: Dilinie FernandoShawn Marie LaCasseKristin Elizabeth Price Wiglesworth
  • Applicant: Pfizer Inc.
  • Applicant Address: US NY New York
  • Assignee: Pfizer Inc.
  • Current Assignee: Pfizer Inc.
  • Current Assignee Address: US NY New York
  • Agent Richard V. Zanzalari
  • International Application: PCT/IB2018/058966 WO 20181114
  • International Announcement: WO2019/102311 WO 20190531
  • Main IPC: C07D471/10
  • IPC: C07D471/10
Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-OXO-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypryridin-2-YL)benzoic acid
Abstract:
The invention provides the tris salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4′-piperidine]-1′-carbonyl)-6-methoxypyridin-2-yl)benzoic acid as a crystalline anhydrous or tri-hydrate; as well as polymorphs, pharmaceutical compositions, dosage forms, and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase (ACC) enzyme(s) in an animal.
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