Invention Grant
- Patent Title: Process for preparing immunoglobulin compositions
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Application No.: US16320900Application Date: 2017-07-26
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Publication No.: US11325964B2Publication Date: 2022-05-10
- Inventor: Oliver Maneg , Achim Hannappel , Alexander Moehlenkamp-Roettger , Wolfgang Moeller , Dieter Rudnick
- Applicant: Biotest AG
- Applicant Address: DE Dreieich
- Assignee: Biotest AG
- Current Assignee: Biotest AG
- Current Assignee Address: DE Dreieich
- Agency: Lewis Kohn Walker LLP
- Agent David M. Kohn
- Priority: EP16181493 20160727
- International Application: PCT/EP2017/068914 WO 20170726
- International Announcement: WO2018/019898 WO 20180201
- Main IPC: C07K16/06
- IPC: C07K16/06 ; C07K1/30 ; C07K1/22 ; G01N33/68

Abstract:
A process for the preparation of pharmaceutically acceptable immunoglobulin compositions from plasma-derived immunoglobulin fractions which allows the parallel preparation of immunoglobulin compositions enriched in IgG, IgM and IgA. In this process, immunoglobulin contained in Cohn fraction I/II/III or Kistler Nitschmann fraction A+I is resolubilized at conductivities of at least 1 mS/cm, and following removal of contaminating protein the resolubilized immunoglobulin is subjected to anion exchange chromatography to obtain IgG- and IgM/IgA-enriched immunoglobulin compositions. The IgG-enriched immunoglobulin composition is further subjected to treatment with a cation exchange material to obtain an immunoglobulin composition having a reduced properdin content.
Public/Granted literature
- US20190161533A1 Process for Preparing Immunoglobulin Compositions Public/Granted day:2019-05-30
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