Invention Grant
- Patent Title: Bispecific antigen-binding constructs targeting Her2
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Application No.: US16011048Application Date: 2018-06-18
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Publication No.: US11325981B2Publication Date: 2022-05-10
- Inventor: Nina E. Weisser , Gordon Yiu Kon Ng , Grant Raymond Wickman , Surjit Bhimarao Dixit , Eric Escobar-Cabrera , Mario Sanches
- Applicant: Zymeworks Inc.
- Applicant Address: CA Vancouver
- Assignee: Zymeworks Inc.
- Current Assignee: Zymeworks Inc.
- Current Assignee Address: CA Vancouver
- Agency: Goodwin Procter LLP
- Main IPC: C07K16/32
- IPC: C07K16/32 ; A61K39/395 ; A61K47/68 ; A61K45/06 ; C07K16/30 ; G01N33/574 ; A61K39/00
Abstract:
Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
Public/Granted literature
- US20180282429A1 Bispecific Antigen-Binding Constructs Targeting HER2 Public/Granted day:2018-10-04
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